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Reversing Age: Humanity’s Oldest Dream Nears Reality

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Paris (Imran Y. CHOUDHRY) :- Former Press Secretary to the President, Former Press Minister to the Embassy of Pakistan to France, Former MD, SRBC Mr. Qamar Bashir analysis : Human beings have always resisted the idea that aging and death are unavoidable. Civilizations created stories about fountains of youth, elixirs of life, resurrection and immortality. Egyptian pharaohs were mummified and buried with possessions needed for the afterlife, although this reflected religious beliefs about spiritual continuity rather than a scientific plan to regenerate their bodies. Modern science fiction transformed the same ancient longing into suspended animation, imagining astronauts sleeping for centuries before awakening unchanged at distant destinations.
Until recently, however, restoring youth to an old body belonged almost entirely to mythology. Medicine could treat individual diseases, exercise could preserve strength and nutrition could reduce health risks, but nothing could instruct an aged cell to become biologically younger. Research into cellular reprogramming has made that possibility scientifically conceivable—although it remains far from proven in human beings.
The sequencing of the human genome and advances in molecular biology allowed scientists to study how genes behave as organisms grow older. Contrary to some popular explanations, aging is not controlled by one gene containing a predetermined expiration date. DNA itself can accumulate mutations and other damage, while mitochondria malfunction, proteins lose their proper form, stem cells become exhausted and senescent cells accumulate.
Another important process is epigenetic change. Epigenetic markers act like instructions telling cells which genes to activate or silence. The underlying DNA sequence may remain substantially the same, but cells can become less effective at reading and executing their instructions. Patterns of DNA methylation change predictably enough with age that researchers use them to construct “epigenetic clocks.”
Scientists have also observed a remarkable rejuvenation process during reproduction. Although an egg and sperm come from adults, a resulting embryo does not begin life at the biological age of its parents. During early development, many age-associated epigenetic markers are reset. The crucial question is whether part of that resetting process can be activated later in life without erasing a cell’s identity or causing cancer.
In 2006, Shinya Yamanaka discovered that four genes—Oct4, Sox2, Klf4 and c-Myc—could return mature cells to a state resembling embryonic stem cells. These became known as the Yamanaka factors. The discovery earned him the 2012 Nobel Prize, but applying all four factors inside a living organism can be dangerous. Excessive reprogramming may cause cells to lose their identities or form tumors.
Researchers subsequently explored “partial reprogramming”: turning back some biological markers of age while allowing cells to remain, for example, functioning skin, muscle or nerve cells.
In a landmark 2020 Nature study, researchers associated with David Sinclair’s Harvard laboratory used three factors—Oct4, Sox2 and Klf4, collectively called OSK—on retinal ganglion cells in mice. The treatment restored more youthful patterns of gene expression, promoted nerve regeneration and improved vision in aged mice and mouse models of glaucoma. The experiment supported the extraordinary possibility that old mammalian cells retain recoverable information about their younger state.
Other researchers have reported encouraging results involving muscle, skin and organs in animals. Yet rejuvenating cells in a mouse, or even improving a particular tissue in a primate, is not equivalent to reversing the age of an entire human being. Animal findings frequently fail when transferred to people, and the dangers of gene therapy and uncontrolled cell growth remain serious.
The field crossed an important threshold in 2026. The U.S. Food and Drug Administration cleared Life Biosciences to begin a Phase 1 trial of ER-100, an experimental epigenetic-reprogramming therapy for optic neuropathies, including open-angle glaucoma and non-arteritic anterior ischemic optic neuropathy.
This should be described precisely. It is not yet a trial proving that human aging can be reversed, nor is it intended to make participants generally younger. It is an early trial designed primarily to evaluate safety and tolerability in a small number of patients, while also observing whether visual function improves.
The eye is a logical starting point because treatment can be delivered locally and monitored closely. A harmful reaction may be easier to contain than it would be after attempting to reprogram the liver, brain or entire body. Even if the therapy restores some vision, years of larger trials would be needed before scientists could establish its effectiveness and understand its long-term cancer risk.
Still, successful rejuvenation of a human tissue would represent a historic medical advance. It could open a route toward treating diseases once considered irreversible rather than immediately producing ageless human beings.
The economic implications could be immense because aging contributes simultaneously to cancer, cardiovascular disease, dementia, diabetes, frailty and many other conditions. A therapy that delayed several diseases together could generate more value than treating each one separately after it appeared.
A 2021 study co-written by economists Andrew Scott and Martin Ellison and geneticist David Sinclair estimated that slowing aging sufficiently to add one year to American life expectancy would be worth approximately $38 trillion; a 10-year gain was valued at $367 trillion. These figures represent an estimated aggregate social willingness to pay—including the value assigned to healthier and longer lives.
A later international study estimated that a one-year improvement in healthy longevity could produce an annual welfare benefit equivalent to roughly 4 to 5 percent of GDP. The benefit would come through healthier workers, longer productive careers, reduced disability, lower demand for expensive late-life care and the intrinsic value people place on living well for longer.
Pakistan offers a different but equally important case. Its population reached approximately 255 million in 2025, life expectancy was about 68 years and nominal GDP was approximately $407 billion. Only 3.55 percent of the population was 65 or older in the 2023 census, while nearly 56 percent was of working age.
Applying the international estimate mechanically, a one-year improvement in healthy longevity might carry an annual welfare value equivalent to approximately $16 billion to $20 billion—4 to 5 percent of Pakistan’s present GDP.
The potential is enormous for the least developed and developing countries. These countries could retain experienced doctors, teachers, engineers, farmers and entrepreneurs for longer. Families might spend less on chronic illness, while healthier older adults could remain independent instead of requiring full-time care. Reduced disability could also increase household savings and national productivity.
Longer lives would also affect employment, pensions, inheritance, housing and population growth. If retirement ages remained unchanged, the fiscal burden could rise. If careers became longer without creating new jobs, younger workers could face blocked advancement. Women might experience new social pressures concerning fertility and caregiving. Religious scholars, ethicists, physicians and legislators would need to consider whether rejuvenation is simply medical treatment or something requiring a new ethical framework.
However, where developed countries are already in this crucial race, the third world countries and developing countries should not wait for the technology to arrive. It should strengthen biotechnology research, establish gene-therapy regulations, train geneticists and bioethicists, and negotiate policies ensuring that successful treatments are not restricted permanently to the wealthy. Public investment must continue prioritizing vaccines, sanitation, nutrition and primary care even while preparing for advanced medicine.
Humanity is not yet approaching immortality. It may, however, be approaching the ability to repair particular tissues by restoring some of their youthful biological instructions. If that achievement expands safely from eyes to other organs, it could transform medicine and economics. The greatest challenge will not only be making a longer, healthier life possible—but ensuring that its benefits belong to humanity rather than to a privileged minority.

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‘Great result for Canada’, says Carney as Alberta votes to reject separatism

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Prime Minister Mark Carney says an overwhelming vote by people in Alberta to remain part of Canada is a “great result” for the country.

Speaking to reporters as he walked into a cabinet meeting on Tuesday, Carney said he was “thrilled that Albertans have chosen unity” by rejecting a proposal to pursue separation through a binding referendum.

Preliminary results indicate more than two-thirds chose Canada over a push for independence for the province, according to Elections Alberta.

Monday’s referendum was the result of a months-long campaign by separatists in the western Canadian province to get a public vote on the issue.

Provincial leader Danielle Smith welcomed the initial results, commenting: “Albertans have voted for a stronger Alberta in a united Canada.”

Premier Smith herself opposed the separatist push but said the public will for a vote was undeniable, and many supporters of her own political party – United Conservative Party – were in the separatist camp.

Smith said she would address Albertans later on Tuesday on the path forward for the province.

In making the case for independence from Canada, many of the separatists said the oil-rich province’s economic growth had been stifled by the environmental policies of Canada’s central government in Ottawa.

But those who opposed a breakup – including Carney – called for Canada to present a united front in the face of external pressures, including an ongoing trade war with the United States.

“They’ve chosen to build together,” Carney said. “They’ve chosen to continue to take care of each other, to move forward, to move forward together, with purpose, high ambition.”

Carney added that he had spoken to Smith that morning and discussed “moving forward in the spirit of cooperative federalism, including on issues of immigration, other common priorities”.

Over the past year, the prime minister has worked with Smith on a number of shared goals, including pushing for an oil pipeline to the Pacific coast.

At a pro-separatist watch party in Edmonton, the hum of upbeat chatter quickly quieted as those presentsaw the projected results.

After overnight vote projections were published by Canadian broadcaster CBC and others, the mood soured. The watch party attended by the BBC packed up quickly, and people went home.

One of the separatist leaders, Jeffrey Rath, struck a defiant tone, however, vowing that “our movement isn’t stopping and we’re continuing to move forward”.

Speaking to the BBC World Service’s Newsday programme, Rath, a lawyer based in Calgary, said he saw Monday’s vote as a “first step” which had taught the movement some “valuable lessons”.

Asked whether his movement would push to keep holding votes on independence until it got the result it wanted, he responded “why not?”, and insisted that “the math and the economics” all added up on his side of the argument.

Wearing a matching cream-coloured hat and jacket, Jeffrey Rath appears at a watch party overnight after an independence vote in Alberta
Separatist leader Jeffrey Rath was defiant even as results went against him

Premier Scott Moe, from the province of Saskatchewan, said he was glad Albertans chose unity, but added that “there is still work to be done on improving how Western Canada is treated by Ottawa”.

Pierre Poilievre, the leader of Canada’s Conservative party and a member of parliament from Alberta, said on social media that “the promise of Canada is worth fighting for”.

“Now our focus must be on results in people’s lives: affordable food and homes, safe streets, strong borders, and less immigration,” he said.

Smith called the vote after a grassroots group gathered about 300,000 signatures on a petition seeking a binding referendum on separation.

The petition was blocked by a judge, saying it failed to consult indigenous First Nations people – however, Smith opted to go ahead with the ballot.

Another group collected signatures for its own petition that opposed separation, which was signed by more than 400,000 people.

The key question on Monday’s voting paper asked: “Should Alberta remain a province of Canada or should the Government of Alberta commence the legal process required under the Canadian Constitution to hold a binding provincial referendum on whether or not Alberta should separate from Canada?”

It’s the first time a Canadian province has weighed the issue of separation since Quebec’s two referendums, in 1980 in 1995.

Both of those were unsuccessful, but Alberta separatists believe Quebec used the threat of independence to gain significant political leverage over Canada’s central government.

Smith said before the vote that if Albertans chose the remain option, a binding referendum on separation would not be held – at least, not while she was in power.

Getty Images A group of people wave Canadian flags during an event in Edmonton where they have been following the results of a vote on whether or not Alberta should separate from the rest of Canada
Those who favoured remaining part of the Canada cheered the result at an event in Edmonton

Despite the projected results, the conversation around Albertan sovereignty is not over.

Separatists leaders have indicated that they plan to try and push Smith out of power within her United Conservative Party, in the hope of installing a leader who is more sympathetic to their cause.

Another separatist leader, Mitch Sylvestre, told the BBC on polling day that “a lot of work will have to be done” to curb the appetite for independence if his side did lose.

Although responses to the referendum question were tallied first, there were nine other non-binding questions on Monday’s ballot paper.

Five of these dealt with immigration, while the other four focused on the Canadian constitution.

Early results suggest that most will pass, including proposals for the province to take increased control over immigration levels.

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160 Global Intellectuals Sound Doomsday Alarm:

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Capitalist Greed and Fossil Fuels Threaten Human Civilization

Columnist: Zeeshan Khan

We are distressed by the deaths and devastation caused by floods, and we are being told that in the solar universe revolving around the sun, the only cradle of human life, our Earth, is under the threat of coal, oil and gas bombs which have the capacity to cause destruction far greater than the combined power of atom, hydrogen and cobalt bombs, and it is rapidly rushing towards doomsday.

Those who are telling and warning us are 160 intellectuals belonging to 46 countries of the world, who have received world-level awards and prizes for their outstanding services and performance on the subject of environmental pollution. They have published a joint appeal in a full-page advertisement in the New York Times and all other prominent newspapers of the world, in which it is said that thought should be given to foiling the last attempts to destroy human life and civilization, otherwise the world of colour and fragrance, sound and melody, beauty and love will end, will be extinguished, and everything will end with it.

It has been told that the profit-seeking of the capitalist system, which has touched new extremes of greed for wealth, has also crossed the extremes of interfering with natural seasons due to the enormous use of coal, oil and gas, because of which global warming can increase by six degrees, which can completely change the climatic conditions of the world. The earth can refuse to grow grain, water to quench thirst can become extinct, the world can enter its last war for life, the garment of human civilization can be torn to pieces. These apprehensions have been expressed for the last century, and for the last quarter century, emphasis has also been laid on efforts to handle and improve this situation, but the countries suffering from greed for wealth of the capitalist system all over the world, including America, are busy in thwarting these efforts and have brought the world along with human life and civilization to the last edge of destruction.

The 160 intellectuals have appealed to all sympathetic institutions, associations and groups of the human world that, in their own interest and in the interest of their future, they should protest against those running the industries engaged in the abundant use of coal, oil and gas, and refrain from actions that further worsen the conditions of “global warming” and turn the whole world into a blazing furnace, and also try to think that if there will be no human population in the world, where will they sell their products and from where will they earn profit? The economy and market shops also need customers. If there are no customers, how will markets run? If in the six degrees of global warming, i.e., unbearable heat, the whole world is made into Hiroshima and Nagasaki, then who will survive? Why does this not enter the minds of the profit-seekers of the capitalist system?

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Israel’s Global Reach: From Latin America to Africa and Asia

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Paris (Imran Y. CHOUDHRY) :- Former Press Secretary to the President, Former Press Minister to the Embassy of Pakistan to France, Former MD, SRBC Mr. Qamar Bashir analysis : Israel’s expanding international reach raises a question that governments can no longer comfortably avoid: when does cooperation become dependence, and when does dependence begin to compromise sovereignty? Weapons, surveillance systems, intelligence partnerships, diplomatic advocacy and investment can establish enduring influence inside another country’s institutions. Examined together, these relationships reveal how a state can acquire leverage far beyond its territory without formally governing the societies affected by its decisions.
The central issue is the conversion of access into power. A weapons contract opens a relationship with a defense ministry. Technical support creates continuing contact with military personnel. Surveillance technology enters intelligence institutions. Political advocacy cultivates sympathetic decision-makers. Commercial partnerships establish constituencies interested in preserving cooperation. These channels can reinforce one another until challenging the relationship carries significant institutional and political costs. Influence becomes most consequential when governments stop asking whether those costs have narrowed their freedom to act.
Ideology matters because it shapes how political leaders justify the exercise of power. Religious nationalism can turn territorial ambitions into sacred obligations and portray compromise as betrayal. Where officials invoke divine entitlement or historical destiny, their language deserves close examination against their policies. The danger is the translation of claims about exceptional entitlement into governmental practice: unequal rights, territorial expansion or the belief that ordinary restraints should yield to a privileged national mission.
Such claims must be attached to identifiable leaders, movements and decisions. Their political force lies in what they authorize. A government that presents its objectives as beyond legitimate challenge creates conditions in which critics become enemies and civilian suffering becomes an acceptable instrument. International partners then face a choice: impose meaningful limits or help normalize exceptional treatment. Strategic friendship becomes dangerous when it functions as permission to evade accountability.
Israel’s international security industry supplies material foundations for its reach. Its defense ministry reported approximately $14.8 billion in new export contracts during 2024. These transactions can establish relationships lasting far beyond delivery. Advanced equipment requires maintenance, training, replacement parts and software. A government purchasing such systems must consider the political implications of relying on an external supplier for essential capabilities. The resulting vulnerability deserves as much attention as the advertised military advantage.
Latin America illustrates several pathways through which these relationships develop. Guatemala’s military governments received Israeli arms and assistance during a period of brutal repression. Colombia’s longstanding reliance on Israeli equipment, including Kfir aircraft and Galil rifles, complicated disengagement when diplomatic relations broke down. Argentina under Javier Milei and Honduras under Juan Orlando Hernández supplied prominent diplomatic backing through commitments concerning Jerusalem. Ecuador under Daniel Noboa pursued cooperation across defense, security, agriculture and water. Together, these cases show military, political and developmental relationships creating multiple points of institutional attachment.
Elsewhere, diplomatic openings and strategic partnerships expand the network. Bolivia restored relations in December 2025. Venezuela’s foreign ministry confirmed continuing technical cooperation following Israeli earthquake assistance in 2026. Recognition of Somaliland introduced Israel into a sensitive sovereignty dispute in the Horn of Africa. India developed extensive defense cooperation, while Austria established a strategic partnership. These relationships differ, but their cumulative significance is international access across security, technology, development and diplomacy. Each deserves examination for the commitments it creates and the interests it advances.
Political lobbying adds another layer. Former Australian foreign minister Bob Carr criticized what he considered excessive pressure from a hardline pro-Israel lobby on government policy. His account raises a fundamental democratic question: can elected officials exercise independent judgment when organized advocacy enjoys privileged access to executive leadership? The answer requires examining meetings, funding, communications and policy changes. Citizens should know whether decisions reflect publicly defensible national interests or pressure operating beyond effective scrutiny.
Surveillance exposes an especially intrusive form of power. Citizen Lab has documented Pegasus attacks involving journalists and human rights defenders. Such capabilities can penetrate the communications through which societies investigate corruption and organize opposition. Responsibility extends through the supply chain, from developers and licensing authorities to purchasing agencies and political leadership. Governments that conceal surveillance abuses cannot credibly claim to protect the freedoms those abuses undermine.
Economic sovereignty requires equally rigorous scrutiny. Banking infrastructure, telecommunications, investment platforms and critical software should be examined for ownership, access rights, contractual dependence and security vulnerabilities.
Claims about foreign control must be established through records and technical evidence. Governments should identify who can access sensitive information, interrupt essential services or influence strategic decisions. Confidential contracts cannot substitute for public accountability where national systems and citizens’ rights are at stake.
The United States provides the principal institutional foundation of Israel’s strategic support. Its longstanding military-assistance framework makes clear that international protection rests on identifiable decisions by legislators and administrations. Those decisions carry responsibility. Officials cannot authorize assistance and then treat its foreseeable consequences as someone else’s concern. An alliance becomes a mechanism of impunity when support continues without meaningful examination of conduct.
Gaza gives this argument its moral urgency. UN satellite analysis based on July 2025 imagery identified damage affecting approximately 78 percent of structures. The scale demands answers from Israeli authorities and the governments sustaining their military and diplomatic position. Palestinian rights cannot remain subordinate to the convenience of strategic partnerships. International standards lose their authority when powerful relationships determine whose suffering produces consequences.
Every government should therefore audit its dependencies, disclose sensitive agreements, investigate unlawful surveillance and scrutinize political influence. Where relationships facilitate abuse or compromise independent decision-making, they should be restricted, renegotiated or ended through lawful processes. Sovereignty requires the capacity to refuse.
Israel’s international influence deserves sustained scrutiny because power exercised through dispersed institutions can escape the accountability attached to visible force. The response must be concrete: expose the mechanisms, identify the beneficiaries and impose enforceable limits. No government should enjoy exceptional permission to override another society’s independence or another people’s rights.

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